Michael Carrick makes two changes to the Manchester United side that lost at Newcastle last time out.
Amad Diallo replaces Benjamin Sesko in attack, while Diogo Dalot comes in for Noussair Mazraoui.
Sesko and Mazraoui are both on the bench, where they are joined by Mason Mount, who has missed six games due to injury.
Manchester United XI: Lammens, Dalot, Yoro, Maguire, Shaw, Casemiro, Mainoo, Amad, Fernandes, Cunha, Mbeumo.
Subs: Bayindir, Mazraoui, Mount, Zirkzee, Malacia, Ugarte, Heaven, Sesko, T Fletcher.
Aston Villa captain John McGinn starts for the first time since injuring his knee against Everton on 18 January, while Tyrone Mings and Ross Barkley are also included as Unai Emery makes three changes from the midweek Europa League win at Lille.
On-loan Jadon Sancho misses out as he is not allowed to play against his parent club. Douglas Luiz and Pau Torres drop to the bench.
Aston Villa XI: Martinez, Bogarde, Konsa, Mings, Digne, McGinn, Onana, Barkley, Rogers, Buendia, Watkins.
Subs: Bizot, Lindelof, Elliott, Torres, Andres Garcia, Abraham, Douglas Luiz, Maatsen, Bailey.