West Ham face bottom club Wolves on Friday – their first of four home games in the run-in.
The Hammers then face Brentford, Everton and Newcastle, who are all chasing a European spot, and current league leaders Arsenal.
If it goes down to the wire, then the final game of the season between West Ham and Leeds could be all or nothing.
Unlike West Ham, Tottenham have more away games in their run-in.
Yet that could in fact favour Spurs given they possess the worst home record in the Premier League this season, having won just two of their 16 home games.
Roberto de Zerbi will need to make an immediate impact as they travel to Sunderland and then host his former club Brighton the following week.
Spurs host Leeds on 11 May in what could be an important game in the fight for survival, before two tricky final games against Chelsea and Everton.