Sunday, March 15

Burning Rock Reports Third Quarter 2025 Financial Results


Burning Rock Biotech Limited
Burning Rock Biotech Limited

GUANGZHOU, China, Nov. 20, 2025 (GLOBE NEWSWIRE) — Burning Rock Biotech Limited (NASDAQ: BNR, the “Company” or “Burning Rock”), a company focused on the application of next generation sequencing (NGS) technology in the field of precision oncology, today reported financial results for the three months ended September 30, 2025.

Recent Business Updates

  • Therapy Selection

    • Presented study results at the Cell Reports Medicine on esophageal squamous cell carcinoma in September 2025. “Integrating ctDNA with clinical response evaluation improves residual disease detection post-neoadjuvant chemoradiotherapy to support organsparing strategies and that postoperative ctDNA stratifies recurrence risk beyond pathological response to inform adjuvant immunotherapy decisions”.

  • Early Detection

    • PROMISE study test results presented at The Innovation in September 2025. “The PROMISE study was conducted to investigate the feasibility of a multi-omics integration strategy in multi-cancer detection blood tests across nine types of cancers in head and neck (excluding nasopharynx), esophagus, lung, stomach, liver, biliary tract, pancreas, colorectum, and ovary……Compared to the methylation-based classifier, the multimodal classifier combining methylation and protein features, exhibited an improved sensitivity of 75.1% (95% 75 confidence interval [CI], 69.3%–80.3%) at the same specificity of 98.8% with the accuracy of top predicted origin (TPO1) of 73.1% (95% CI, 66.2%–79.2%)”.

  • Pharma Services

    • The OncoGuide™ OncoScreen™ Plus CDx System based on OncoScreen™ Plus to be used as a companion diagnostic for AstraZeneca’s capivasertib has received Manufacturing and Marketing Approval from Japan’s Ministry of Health, Labour and Welfare (MHLW) in September, 2025.

Third Quarter 2025 Financial Results

Total revenues were RMB131.6 million (US$18.5 million) for the three months ended September 30, 2025, representing a 2.3% increase from RMB128.6 million for the same period in 2024.

  • Revenue generated from in-hospital business was RMB52.8 million (US$7.4 million) for the three months ended September 30, 2025, representing a 17.1% decrease from RMB63.8 million for the same period in 2024, driven by a decrease in sales volume.

  • Revenue generated from central laboratory business was RMB36.8 million (US$5.2 million) for the three months ended September 30, 2025, representing a 7.9% decrease from RMB40.0 million for the same period in 2024, primarily attributable to a decrease in the number of tests, as we continued our transition towards in-hospital testing.

  • Revenue generated from pharma research and development services was RMB42.0 million (US$5.9 million) for the three months ended September 30, 2025, representing a 68.6% increase from RMB24.9 million for the same period in 2024, primarily attributable to an increased development and testing services performed for our pharma customers.

Cost of revenues was RMB32.8 million (US$4.6 million) for the three months ended September 30, 2025, representing an 10.9% decrease from RMB36.8 million for the same period in 2024.

Gross profit was RMB98.8 million (US$13.9 million) for the three months ended September 30, 2025, representing a 7.6% increase from RMB91.8 million for the same period in 2024. Gross margin was 75.1% for the three months ended September 30, 2025, compared to 71.4% for the same period in 2024. By channel, gross margin of central laboratory business and in-hospital business were 81.8% and 71.8% for the three months ended September 30, 2025, compared to 83.2% and 73.0% during the same period in 2024, primarily due to the cost reduction caused by the rent subsidy for the headquarter building in the third quarter of 2024; gross margin of pharma research and development services was 73.4% for the three months ended September 30, 2025, compared to 48.2% during the same period of 2024, primarily due to the significant increase in revenue from high-margin companion diagnostic (CDx) projects.

Non-GAAP gross profit, which excludes depreciation and amortization expenses, was RMB100.9 million (US$14.2million) for the three months ended September 30, 2025, representing a 3.2% increase from RMB97.8 million for the same period in 2024. Non-GAAP gross margin was 76.7% for the three months ended September 30, 2025, compared to 76.0% for the same period in 2024.

Operating expenses were RMB115.0 million (US$16.2 million) for the three months ended September 30, 2025, representing a 11.9% decrease from RMB130.4 million for the same period in 2024. The decrease was primarily driven by decreases in amortized expense on share-based compensation, budget control measures and headcount reduction to improve the Company’s operating efficiency.

  • Research and development expenses were RMB41.5 million (US$5.8 million) for the three months ended September 30, 2025, representing a 15.6% decrease from RMB49.2 million for the same period in 2024, primarily due to (i) a decrease in the expenditure for research projects; (iii) a decrease in amortized expense on share-based compensation; and (iv) a decrease in amortized expenses for office building decoration.

  • Selling and marketing expenses were RMB41.8 million (US$5.9 million) for the three months ended September 30, 2025, representing a 13.6% decrease from RMB48.4 million for the same period in 2024, primarily due to (i) a decrease in staff cost resulted from the reorganization of the sales department and improvement in operating efficiency; (ii) a decrease in amortized expense on share-based compensation; and (iii) a decrease in amortized expenses for office building decoration.

  • General and administrative expenses were RMB31.7 million (US$4.5 million) for the three months ended September 30, 2025, representing a 3.6% decrease from RMB32.9 million for the same period in 2024, primarily due to (i) a decrease in the general and administrative personnel’s staff cost; (ii) a decrease in amortized expense on share-based compensation; and partially offset by (i) an increase in impairment expenses for accounts receivables and contract assets; (iii) an increase in operating lease.

Net loss was RMB16.8 million (US$2.4 million) for the three months ended September 30, 2025, compared to RMB35.7 million for the same period in 2024.

Cash, cash equivalents and restricted cash were RMB467.0 million (US$65.6 million) as of September 30, 2025.

About Burning Rock

Burning Rock Biotech Limited (NASDAQ: BNR), whose mission is to guard life via science, focuses on the application of next generation sequencing (NGS) technology in the field of precision oncology. Its business consists of i) NGS-based therapy selection testing for late-stage cancer patients, and ii) cancer early detection, which has moved beyond proof-of-concept R&D into the clinical validation stage.

For more information about Burning Rock, please visit: ir.brbiotech.com.

Safe Harbor Statement

This press release contains forward-looking statements. These statements constitute “forward-looking” statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and as defined in the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as “will,” “expects,” “anticipates,” “future,” “intends,” “plans,” “believes,” “estimates,” “target,” “confident” and similar statements. Burning Rock may also make written or oral forward-looking statements in its periodic reports to the SEC, in its annual report to shareholders, in press releases and other written materials and in oral statements made by its officers, directors or employees to third parties. Statements that are not historical facts, including statements about Burning Rock’s beliefs and expectations, are forward-looking statements. Such statements are based upon management’s current expectations and current market and operating conditions, and relate to events that involve known or unknown risks, uncertainties and other factors, all of which are difficult to predict and many of which are beyond Burning Rock’s control. Forward-looking statements involve risks, uncertainties and other factors that could cause actual results to differ materially from those contained in any such statements. All information provided in this press release is as of the date of this press release, and Burning Rock does not undertake any obligation to update any forward-looking statement as a result of new information, future events or otherwise, except as required under applicable law.

Non-GAAP Measures

In evaluating the business, the Company considers and uses non-GAAP measures, such as non-GAAP gross profit and non-GAAP gross margin, as supplemental measures to review and assess operating performance. The presentation of these non-GAAP financial measures is not intended to be considered in isolation or as a substitute for the financial information prepared and presented in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”). The company defines non-GAAP gross profit as gross profit excluding depreciation and amortization. The company defines non-GAAP gross margin as gross margin excluding depreciation and amortization.

The company presents these non-GAAP financial measures because they are used by management to evaluate operating performance and formulate business plans. The company believe non-GAAP gross profit and non-GAAP gross margin excluding non-cash impact of depreciation and amortization reflect the company’s ongoing business operations in a manner that allows more meaningful period-to-period comparisons.

Contact: IR@brbiotech.com

 

Selected Operating Data

 

 

 

As of

 

September 30,
2024

December 31,
2024

March 31,
2025

June 30,
2025

September 30,
2025

In-hospital Channel:

 

 

 

 

 

Pipeline partner hospitals(1)

30

29

30

30

31

Contracted partner hospitals(2)

61

63

63

63

63

Total number of partnerhospitals

69

92

93

93

94

(1)

Refers to hospitals that are in the process of establishing in-hospital laboratories, laboratory equipment procurement or installation, staff training or pilot testing using the Company’s products.

(2)

Refers to hospitals that have entered into contracts to purchase the Company’s products for use on a recurring basis in their respective in-hospital laboratories the Company helped them establish. Kit revenue is generated from contracted hospitals.

 

 

Selected Financial Data

 

 

 

 

 

 

 

 

 

 

 

For the three months ended

 

For the nine months ended

Revenues

 

September 30,
2024

 

September 30,
2025

 

September 30,
2024

 

September 30,
2025

 

 

(RMB in thousands)

 

(RMB in thousands)

Central laboratory channel

 

39,984

 

36,811

 

136,371

 

115,968

In-hospital channel

 

63,769

 

52,847

 

181,028

 

173,030

Pharma research and development channel

 

24,891

 

41,959

 

72,401

 

124,255

Total revenues

 

128,644

 

131,617

 

389,800

 

413,253

 

 

 

 

 

 

 

 

 

 

 

For the three months ended

 

For the nine months ended

Revenues by location of customer

 

September 30,
2024

 

September 30,
2025

 

September 30,
2024

 

September 30,
2025

 

 

(RMB in thousands)

 

(RMB in thousands)

Overseas

 

25,840

 

17,214

 

59,553

 

79,079

Mainland China

 

102,804

 

114,403

 

330,247

 

334,174

Total Revenues

 

128,644

 

131,617

 

389,800

 

413,253

 

 

 

 

 

 

 

 

 

 

 

For the three months ended

 

For the nine months ended

Gross profit

 

September 30,
2024

 

September 30, 2025

 

September 30,
2024

 

September 30, 2025

 

 

(RMB in thousands)

 

(RMB in thousands)

Central laboratory channel

 

33,262

 

30,126

 

108,688

 

98,254

In-hospital channel

 

46,580

 

37,925

 

129,830

 

128,310

Pharma research and development channel

 

12,004

 

30,793

 

34,460

 

77,784

Total gross profit

 

91,846

 

98,844

 

272,978

 

304,348

 

 

 

 

 

 

 

 

 

 

 

For the three months ended

 

For the nine months ended

Share-based compensation expenses

 

September 30,
2024

 

September 30,
2025

 

September 30,
2024

 

September 30,
2025

 

 

(RMB in thousands)

 

(RMB in thousands)

Cost of revenues

 

289

 

301

 

1,349

 

889

Research and development expenses

 

3,180

 

73

 

27,475

 

1,603

Selling and marketing expenses

 

1,917

 

624

 

3,657

 

2,013

General and administrative expenses

 

4,732

 

2,831

 

115,129

 

6,249

Total share-based compensation expenses

 

10,118

 

3,829

 

147,610

 

10,754

 

 

 

 

 

 

 

 

 

Burning Rock Biotech Limited
Unaudited Condensed Statements of Comprehensive Loss
(in thousands, except for number of shares and per share data)

 

 

 

For the three months ended

 

September 30,
2024

 

December 31,
2024

 

March 31,
2025

 

June 30,
2025

 

September 30,
2025

 

September 30,
2025

 

 

RMB

 

RMB

 

RMB

 

RMB

 

RMB

 

US$

 

Revenues

128,644

 

126,022

 

133,082

 

148,554

 

131,617

 

18,488

 

Cost of revenues

(36,798

)

(36,600

)

(35,681

)

(40,451

)

(32,773

)

(4,604

)

Gross profit

91,846

 

89,422

 

97,401

 

108,103

 

98,844

 

13,884

 

Operating expenses:

 

 

 

 

 

 

Research and development expenses

(49,150

)

(52,203

)

(40,389

)

(49,770

)

(41,469

)

(5,825

)

Selling and marketing expenses

(48,411

)

(46,730

)

(40,888

)

(38,413

)

(41,808

)

(5,873

)

General and administrative expenses

(32,874

)

(37,289

)

(31,303

)

(31,417

)

(31,698

)

(4,453

)

Impairment loss on long-lived assets

 

(35,127

)

 

 

 

 

Total operating expenses

(130,435

)

(171,349

)

(112,580

)

(119,600

)

(114,975

)

(16,151

)

Loss from operations

(38,589

)

(81,927

)

(15,179

)

(11,497

)

(16,131

)

(2,267

)

Interest income

3,173

 

1,814

 

2,581

 

2,226

 

1,744

 

245

 

Interest expense

 

 

 

 

(15

)

(2

)

Other income (expense), net

1

 

4,353

 

(652

)

387

 

7

 

1

 

Foreign exchange loss, net

(129

)

(220

)

(26

)

(574

)

(2,151

)

(302

)

Loss before income tax

(35,544

)

(75,980

)

(13,276

)

(9,458

)

(16,546

)

(2,325

)

Income tax expenses

(201

)

(5,314

)

(224

)

(244

)

(212

)

(30

)

Net loss

(35,745

)

(81,294

)

(13,500

)

(9,702

)

(16,758

)

(2,355

)

Net loss attributable to Burning Rock Biotech Limited’s shareholders

(35,745

)

(81,294

)

(13,500

)

(9,702

)

(16,758

)

(2,355

)

Net loss attributable to ordinary shareholders

(35,745

)

(81,294

)

(13,500

)

(9,702

)

(16,758

)

(2,355

)

Loss per share for class A and class B ordinary shares:

 

 

 

 

 

 

Class A ordinary shares – basic and diluted

(0.35

)

(0.79

)

(0.13

)

(0.09

)

(0.16

)

(0.02

)

Class B ordinary shares – basic and diluted

(0.35

)

(0.79

)

(0.13

)

(0.09

)

(0.16

)

(0.02

)

Weighted average shares outstanding used in loss per share computation:

 

 

 

 

 

 

Class A ordinary shares – basic and diluted

85,902,670

 

86,036,286

 

90,291,658

 

90,357,970

 

90,416,619

 

90,416,619

 

Class B ordinary shares – basic and diluted

17,324,848

 

17,324,848

 

17,324,848

 

17,324,848

 

17,324,848

 

17,324,848

 

Other comprehensive (loss) income, net of tax of nil:

 

 

 

 

 

 

Foreign currency translation adjustments

(4,054

)

6,009

 

(72

)

(243

)

(1,724

)

(242

)

Total comprehensive loss

(39,799

)

(75,285

)

(13,572

)

(9,945

)

(18,482

)

(2,597

)

Total comprehensive loss attributable to Burning Rock Biotech Limited’s shareholders

(39,799

)

(75,285

)

(13,572

)

(9,945

)

(18,482

)

(2,597

)

Burning Rock Biotech Limited
Unaudited Condensed Statements of Comprehensive Loss
(in thousands, except for number of shares and per share data)

 

 

 

For the nine months ended

 

September 30,
2024

 

September 30,
2025

 

September 30,
2025

 

 

RMB

RMB

US$

Revenues

389,800

 

413,253

 

58,049

 

Cost of revenues

(116,822

)

(108,905

)

(15,299

)

Gross profit

272,978

 

304,348

 

42,750

 

Operating expenses:

 

 

 

Research and development expenses

(180,087

)

(131,628

)

(18,490

)

Selling and marketing expenses

(144,174

)

(121,109

)

(17,012

)

General and administrative expenses

(224,349

)

(94,418

)

(13,263

)

Total operating expenses

(548,610

)

(347,155

)

(48,765

)

Loss from operations

(275,632

)

(42,807

)

(6,015

)

Interest income

10,398

 

6,551

 

920

 

Interest expense

 

(15

)

(2

)

Other income, net

353

 

(258

)

(36

)

Foreign exchange gain (loss), net

120

 

(2,751

)

(386

)

Loss before income tax

(264,761

)

(39,280

)

(5,519

)

Income tax expenses

(571

)

(680

)

(96

)

Net loss

(265,332

)

(39,960

)

(5,615

)

Net loss attributable to Burning Rock Biotech Limited’s shareholders

(265,332

)

(39,960

)

(5,615

)

Net loss attributable to ordinary shareholders

(265,332

)

(39,960

)

(5,615

)

Loss per share for class A and class B ordinary shares:

 

 

 

Class A ordinary shares – basic and diluted

(2.58

)

(0.37

)

(0.05

)

Class B ordinary shares – basic and diluted

(2.58

)

(0.37

)

(0.05

)

Weighted average shares outstanding used in loss per share computation:

 

 

 

Class A ordinary shares – basic and diluted

85,467,131

 

90,332,672

 

90,332,672

 

Class B ordinary shares – basic and diluted

17,324,848

 

17,324,848

 

17,324,848

 

Other comprehensive loss, net of tax of nil:

 

 

 

Foreign currency translation adjustments

(2,524

)

(2,039

)

(286

)

Total comprehensive loss

(267,856

)

(41,999

)

(5,901

)

Total comprehensive loss attributable to Burning Rock Biotech Limited’s shareholders

(267,856

)

(41,999

)

(5,901

)

Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets

(In thousands)

 

 

 

As of

 

December 31,
2024

 

September 30,
2025

 

September 30,
2025

 

RMB

 

RMB

 

US$

ASSETS

 

 

 

 

 

Current assets:

 

 

 

 

 

Cash and cash equivalents

519,849

 

463,994

 

65,177

Restricted cash

2,313

 

2,985

 

419

Accounts receivable, net

152,013

 

183,841

 

25,824

Contract assets, net

13,855

 

13,049

 

1,833

Inventories, net

62,625

 

54,469

 

7,651

Prepayments and other current assets, net

25,963

 

20,985

 

2,950

Total current assets

776,618

 

739,323

 

103,854


Non-current assets:

 

 

 

 

 

Property and equipment, net

47,152

 

33,755

 

4,742

Operating right-of-use assets

53,188

 

32,281

 

4,534

Intangible assets, net

421

 

316

 

44

Other non-current assets

7,926

 

6,493

 

912

Total non-current assets

108,687

 

72,845

 

10,232

TOTAL ASSETS

885,305

 

812,168

 

114,086

Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets (Continued)

(in thousands)

 

 

 

As of

 

December 31,
2024

 

September 30,
2025

 

September 30,
2025

 

 

RMB

RMB

US$

LIABILITIES AND SHAREHOLDERS’ EQUITY

 

 

 

Current liabilities:

 

 

 

Accounts payable

33,747

 

34,277

 

4,815

 

Deferred revenue

117,895

 

106,448

 

14,953

 

Accrued liabilities and other current liabilities

89,498

 

76,992

 

10,816

 

Customer deposits

592

 

592

 

83

 

Short-term borrowings

 

200

 

28

 

Current portion of operating lease liabilities

24,567

 

16,603

 

2,332

 

Total current liabilities

266,299

 

235,112

 

33,027

 

Non-current liabilities:

 

 

 

Long-term borrowings

 

1,800

 

253

 

Non-current portion of operating lease liabilities

27,754

 

14,577

 

2,048

 

Other non-current liabilities

10,425

 

11,102

 

1,559

 

Total non-current liabilities

38,179

 

27,479

 

3,860

 

TOTAL LIABILITIES

304,478

 

262,591

 

36,887

 


Shareholders’ equity:

 

 

 

Class A ordinary shares

124

 

120

 

17

 

Class B ordinary shares

21

 

21

 

3

 

Additional paid-in capital

5,002,255

 

5,006,937

 

703,320

 

Treasury stock

(63,264

)

(57,193

)

(8,034

)

Accumulated deficits

(4,200,261

)

(4,240,221

)

(595,620

)

Accumulated other comprehensive loss

(158,048

)

(160,087

)

(22,487

)

Total shareholders’ equity

580,827

 

549,577

 

77,199

 

TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY

885,305

 

812,168

 

114,086

 

Burning Rock Biotech Limited

Unaudited Condensed Statements of Cash Flows

(in thousands)

 

 

 

For the three months ended

 

September
30,2024

 

September
30,2025

 

September 30,
2025

 

 

RMB

RMB

US$

Net cash used in operating activities

(30,278

)

16,394

 

2,303

 

Net cash used in investing activities

(987

)

(2,747

)

(386

)

Net cash generated from financing activities

2

 

 

 

Effect of exchange rate on cash, cash equivalents and restricted cash

(3,537

)

(1,692

)

(237

)

Net decrease in cash, cash equivalents and restricted cash

(34,800

)

11,955

 

1,680

 

Cash, cash equivalents and restricted cash at the beginning of period

533,047

 

455,024

 

63,916

 

Cash, cash equivalents and restricted cash at the end of period

498,247

 

466,979

 

65,596

 

 

 

 

 

 

For the nine months ended

 

September
30,2024

 

September
30,2025

 

September
30,2025

 

 

RMB

RMB

US$

Net cash used in operating activities

(111,323

)

(51,482

)

(7,232

)

Net cash used in investing activities

(3,600

)

(4,071

)

(572

)

Net cash generated from financing activities

2

 

2,000

 

281

 

Effect of exchange rate on cash, cash equivalents and restricted cash

(2,048

)

(1,630

)

(229

)

Net decrease in cash, cash equivalents and restricted cash

(116,969

)

(55,183

)

(7,752

)

Cash, cash equivalents and restricted cash at the beginning of period

615,216

 

522,162

 

73,348

 

Cash, cash equivalents and restricted cash at the end of period

498,247

 

466,979

 

65,596

 

 

 

 

Burning Rock Biotech Limited

Reconciliations of GAAP and Non-GAAP Results

 

 

 

 

For the three months ended

 

September 30,
2024

 

December 31,
2024

 

March 31,
2025

 

June 30,
2025

 

September 30,
2025

 

 

(RMB in thousands)

Gross profit:

 

 

Central laboratory channel

33,262

 

33,153

 

32,191

 

35,937

 

30,126

 

In-hospital channel

46,580

 

29,563

 

43,895

 

46,490

 

37,925

 

Pharma research and development channel

12,004

 

26,706

 

21,315

 

25,676

 

30,793

 

Total gross profit

91,846

 

89,422

 

97,401

 

108,103

 

98,844

 

Add: depreciation and amortization:

 

 

 

 

 

Central laboratory channel

1,277

 

1,010

 

562

 

456

 

231

 

In-hospital channel

798

 

623

 

290

 

389

 

372

 

Pharma research and development channel

3,846

 

2,534

 

2,412

 

1,528

 

1,491

 

Total depreciation and amortization included in cost of revenues

5,921

 

4,167

 

3,264

 

2,373

 

2,094

 

Non-GAAP gross profit:

 

 

 

 

 

Central laboratory channel

34,539

 

34,163

 

32,753

 

36,393

 

30,357

 

In-hospital channel

47,378

 

30,186

 

44,185

 

46,879

 

38,297

 

Pharma research and development channel

15,850

 

29,240

 

23,727

 

27,204

 

32,284

 

Total non-GAAP gross profit

97,767

 

93,589

 

100,665

 

110,476

 

100,938

 

Non-GAAP gross margin:

 

 

 

 

 

Central laboratory channel

86.4%

 

87.0%

 

85.5%

 

89.1%

 

82.5%

 

In-hospital channel

74.3%

 

69.5%

 

76.6%

 

75.0%

 

72.5%

 

Pharma research and development channel

63.7%

 

67.6%

 

64.0%

 

60.2%

 

76.9%

 

Total non-GAAP gross margin

76.0%

 

74.3%

 

75.6%

 

74.4%

 

76.7%

 



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