It could well be O’Neill’s final game in charge of the club, with Columbus Crew manager Wilfried Nancy close to being announced as Brendan Rodgers‘ permanent replacement.
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Here is the team the Irishman has selected, as the Scottish Premiership champions aim for three points.
CELTIC XI: Schmeichel, Donovan, Scales, Trusty, Tierney, McGregor, Engels, Hatate, Yang, McCowan, Maeda.
Subs: Sinisalo, Doohan, Nygren, Balikwisha, Iheanacho, Tounekti, Ralston, Bernardo, Kenny, Murray, Hale, Isiguzo.
Kick-off in Rotterdam this evening is at 5.45pm.