Week 12 of the 2025 college football season could provide a chance for a major shakeup of the College Football Playoff field.
Of the 25 ranked teams in the US LBM Coaches Poll, 23 of them will be in action this weekend, including a grand total of two top-10 matchups in the SEC that could shake up the entire 12-team field. No. 4 Alabama (8-1, 6-0 SEC) takes on No. 10 Oklahoma (7-2, 3-2), while No. 5 Georgia (8-1, 6-1) faces off against No. 10 Texas (7-2, 4-1).
Another key matchup will be No. 9 Notre Dame vs. No. 23 Pittsburgh, which has drawn enough attention for ESPN’s “College GameDay” to return to Pittsburgh for the first time in 20 years.
As has been the case all season, any team could be on upset alert on any given Saturday. Penn State nearly knocked off No. 2 Indiana last week, while No. 14 Vanderbilt avoided an upset at the hands of Auburn in overtime.
Here is an early look at picks, predictions and odds for all of Saturday’s Week 12 games on the 2025 college football schedule:
College football Week 12 game predictions, picks
Odds courtesy of BetMGM as of Sunday, Nov. 9
No. 1 Ohio State vs UCLA
- Date: Saturday, Nov. 15
- Time: 7:30 p.m. ET
- Location: Ohio Stadium (Columbus, Ohio)
- Spread: Ohio State -31.5
Prediction: Ohio State 42, UCLA 10
No. 2 Indiana vs Wisconsin
- Date: Saturday, Nov. 15
- Time: 12 p.m. ET
- Location: Memorial Stadium (Bloomington, Indiana)
- Spread: Indiana -30.5
Prediction: Indiana 38, Wisconsin 10
No. 3 Texas A&M vs South Carolina
- Date: Saturday, Nov. 15
- Time: Noon ET
- Location: Kyle Field (College Station, Texas)
- Spread: Texas A&M -18.5
Prediction: Texas A&M 34, South Carolina 16
No. 4 Alabama vs No. 10 Oklahoma
- Date: Saturday, Nov. 15
- Time: 3:30 p.m. ET
- Location: Bryant-Denny Stadium (Tuscaloosa, Alabama)
- Spread: Alabama -7
Prediction: Alabama 30, Oklahoma 28
No. 5 Georgia vs No. 10 Texas
- Date: Saturday, Nov. 15
- Time: 7:30 p.m. ET
- Location: Sanford Stadium (Athens, Georgia)
- Spread: Georgia -6
Prediction: Georgia 31, Texas 24
No. 7 Ole Miss vs Florida
- Date: Saturday, Nov. 15
- Time: 7 p.m. ET
- Location: Vaught-Hemingway Stadium (Oxford, Mississippi)
- Spread: Ole Miss -13.5
Prediction: Ole Miss 42, Florida 17
No. 8 Texas Tech vs Central Florida
- Date: Saturday, Nov. 15
- Time: 3:30 p.m. ET
- Location: Jones AT&T Stadium (Lubbock, Texas)
- Spread: Texas Tech -23.5
Prediction: Texas Tech 34, UCF 14
No. 9 Notre Dame vs No. 23 Pittsburgh
- Date: Saturday, Nov. 15
- Time: Noon ET
- Location: Acrisure Stadium (Pittsburgh, Pennslyvannia)
- Spread: Notre Dame -10.5
Prediction: Pittsburgh 34, Notre Dame 30
- Date: Saturday, Nov. 15
- Time: 3:30 p.m. ET
- Location: Alumni Stadium (Chestnut Hill, Massachutsetts)
- Spread: Georgia Tech -16.5
Prediction: Georgia Tech 49, Boston College 14
No. 12 BYU vs TCU
- Date: Saturday, Nov. 15
- Time: 10:15 p.m. ET
- Location: LaVell Edwards Stadium (Provo, Utah)
- Spread: BYU -5.5
Prediction: TCU 28, BYU 21
No. 15 Utah vs Baylor
- Date: Saturday, Nov. 15
- Time: 7 p.m. ET
- Location: McLane Stadium (Waco, Texas)
- Spread: Utah -8.5
Prediction: Utah 30, Baylor 28
No. 16 Miami vs NC State
- Date: Saturday, Nov. 15
- Time: 7:30 p.m. ET
- Location: Hard Rock Stadium (Miami Gardens, Florida)
- Spread: Miami -14.5
Prediction: Miami 31, NC State 18
No. 17 Michigan vs Northwestern
- Date: Saturday, Nov. 15
- Time: Noon ET
- Location: Wrigley Field (Chicago)
- Spread: Michigan -10
Prediction: Northwestern 23, Michigan 20
No. 18 Southern California vs Iowa
- Date: Saturday, Nov. 15
- Time: 3:30 p.m. ET
- Location: Los Angeles Memorial Coliseum (Los Angeles)
- Spread: USC -6.5
Prediction: Iowa 30, USC 24
No. 19 Virginia vs Duke
- Date: Saturday, Nov. 15
- Time: 3:30 p.m. ET
- Location: Wallace Wade Stadium (Durham, North Carolina)
- Spread: Duke -6.5
Prediction: Duke 27, Virginia 21
No. 20 Tennessee vs New Mexico State
- Date: Saturday, Nov. 15
- Time: 4:15 p.m. ET
- Location: Neyland Stadium (Knoxville, Tennessee)
- Spread: Tennessee -38.5
Prediction: Tennessee 49, New Mexico State 14
No. 22 Cincinnati vs Arizona
- Date: Saturday, Nov. 15
- Time: Noon ET
- Location: Nippert Stadium (Cincinnati, Ohio)
- Spread: Cincinnati -6
Prediction: Cincinnati 34, Arizona 31
No. 24 Missouri vs Mississippi State
- Date: Saturday, Nov. 15
- Time: 7:45 p.m. ET
- Location: Memorial Stadium (Columbia, Missouri)
- Spread: Missouri -6.5
Prediction: Missouri 30, Mississippi State 20
- Date: Saturday, Nov. 15
- Time: 3:30 p.m. ET
- Location: Bridgeforth Stadium (Harrisonburg, Virginia)
- Spread: James Madison -20.5