Tuesday, February 24

Revealing hidden tissue architecture with mid-infrared dichroism photoacoustic microscopy


  • Holmes, D. F. et al. Corneal collagen fibril structure in three dimensions: structural insights into fibril assembly, mechanical properties, and tissue organization. Proc. Natl. Acad. Sci. USA 98, 7307–7312 (2001).

    Article 
    ADS 

    Google Scholar
     

  • Benjamin, M., Kaiser, E. & Milz, S. Structure-function relationships in tendons: a review. J. Anat. 212, 211–228 (2008).

    Article 

    Google Scholar
     

  • Zeisberg, M. & Kalluri, R. Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. Am. J. Physiol.-Cell Physiol. 304, C216–C225 (2013).

    Article 

    Google Scholar
     

  • Lichtman, J. W. & Conchello, J. A. Fluorescence microscopy. Nat. Methods 2, 910–919 (2005).

    Article 

    Google Scholar
     

  • Parfitt, G. J. Immunofluorescence tomography: high-resolution 3-D reconstruction by serial-sectioning of methacrylate embedded tissues and alignment of 2-D immunofluorescence images. Sci. Rep. 9, 1992 (2019).

    Article 
    ADS 

    Google Scholar
     

  • Lo, R. C. & Kim, H. Histopathological evaluation of liver fibrosis and cirrhosis regression. Clin. Mol. Hepatol. 23, 302–307 (2017).

    Article 

    Google Scholar
     

  • Gong, Y. H., Chen, X. R. & Wu, W. Application of Fourier transform infrared (FTIR) spectroscopy in sample preparation: material characterization and mechanism investigation. Adv. Sample Preparation 11, 100122 (2024).

    Article 

    Google Scholar
     

  • Aghigh, A. et al. Second harmonic generation microscopy: a powerful tool for bio-imaging. Biophysical Rev. 15, 43–70 (2023).

    Article 

    Google Scholar
     

  • Zhang, W. X. et al. Multi-molecular hyperspectral PRM-SRS microscopy. Nat. Commun. 15, 1599 (2024).

    Article 
    ADS 

    Google Scholar
     

  • Park, E. et al. Label-free mid-infrared dichroism-sensitive photoacoustic microscopy for histostructural analysis of engineered heart tissues. Light Sci. Appl. 15, 49 (2026).

    Article 

    Google Scholar
     

  • Xu, M. H. & Wang, L. V. Photoacoustic imaging in biomedicine. Rev. Sci. Instrum. 77, 041101 (2006).

    Article 
    ADS 

    Google Scholar
     

  • Kruger, R. A. et al. Photoacoustic ultrasound (PAUS)—reconstruction tomography. Med. Phys. 22, 1605–1609 (1995).

    Article 

    Google Scholar
     

  • Gu, Y. R. et al. Application of photoacoustic computed tomography in biomedical imaging: a literature review. Bioeng. Transl. Med. 8, e10419 (2023).

    Article 

    Google Scholar
     

  • Zhu, X. Y. et al. Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy. Light Sci. Appl. 11, 138 (2022).

    Article 
    ADS 

    Google Scholar
     

  • Yao, J. J. et al. High-speed label-free functional photoacoustic microscopy of mouse brain in action. Nat. Methods 12, 407–410 (2015).

    Article 

    Google Scholar
     

  • Wang, L. V. & Yao, J. J. A practical guide to photoacoustic tomography in the life sciences. Nat. Methods 13, 627–638 (2016).

    Article 

    Google Scholar
     

  • Yao, J. J. et al. Label-free oxygen-metabolic photoacoustic microscopy in vivo. J. Biomed. Opt. 16, 076003 (2011).

    Article 
    ADS 

    Google Scholar
     

  • He, Y. et al. Label-free imaging of lipid-rich biological tissues by mid-infrared photoacoustic microscopy. J. Biomed. Opt. 25, 106506 (2020).

    Article 
    ADS 

    Google Scholar
     

  • Zhang, C. et al. Label-free photoacoustic microscopy of cytochromes. J. Biomed. Opt. 18, 020504 (2013).

    Article 
    ADS 

    Google Scholar
     

  • Li, X. F. et al. Ultraviolet photoacoustic microscopy with tissue clearing for high-contrast histological imaging. Photoacoustics 25, 100313 (2022).

    Article 

    Google Scholar
     

  • Kim, D. et al. An ultraviolet-transparent ultrasound transducer enables high-resolution label-free photoacoustic histopathology. Laser Photonics Rev. 18, 2300652 (2024).

    Article 
    ADS 

    Google Scholar
     

  • Rong, Q. Z. et al. From ultraviolet to near-infrared: label-free reflection-mode hyperspectral photoacoustic microscopy for single-cell biochemical mapping. GEN Biotechnol. 2, 435–444 (2023).

    Article 

    Google Scholar
     

  • Rong, Q. Z. et al. Label-free photoacoustic imaging of glassfrog development. Photoacoustics 46, 100773 (2025).

    Article 

    Google Scholar
     

  • Pleitez, M. A. et al. Label-free metabolic imaging by mid-infrared optoacoustic microscopy in living cells. Nat. Biotechnol. 38, 293–296 (2020).

    Article 

    Google Scholar
     

  • Visscher, M. et al. Label-free analytic histology of carotid atherosclerosis by mid-infrared optoacoustic microscopy. Photoacoustics 26, 100354 (2022).

    Article 

    Google Scholar
     

  • Shi, J. H. et al. High-resolution, high-contrast mid-infrared imaging of fresh biological samples with ultraviolet-localized photoacoustic microscopy. Nat. Photonics 13, 609–615 (2019).

    Article 
    ADS 

    Google Scholar
     

  • Zhang, D. L. et al. Depth-resolved mid-infrared photothermal imaging of living cells and organisms with submicrometer spatial resolution. Sci. Adv. 2, e1600521 (2016).

    Article 
    ADS 

    Google Scholar
     

  • Yuan, T. et al. Functional live-cell mid-infrared microscopy and spectroscopy by optoacoustic and optothermal detection. Proceedings of SPIE 12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023. San Francisco, California, United States: SPIE, 2023, 1239202.

  • Qu, Y. et al. Dichroism-sensitive photoacoustic computed tomography. Optica 5, 495–501 (2018).

    Article 
    ADS 

    Google Scholar
     

  • Zhou, Y. Y. et al. Single-shot linear dichroism optical-resolution photoacoustic microscopy. Photoacoustics 16, 100148 (2019).

    Article 

    Google Scholar
     

  • Park, E. et al. Azimuth mapping of fibrous tissue in linear dichroism-sensitive photoacoustic microscopy. Photoacoustics 31, 100510 (2023).

    Article 

    Google Scholar
     

  • Yoon, C. et al. Deep learning-based virtual staining, segmentation, and classification in label-free photoacoustic histology of human specimens. Light Sci. Appl. 13, 226 (2024).

    Article 
    ADS 

    Google Scholar
     

  • De Boer, J. F., Hitzenberger, C. K. & Yasuno, Y. Polarization sensitive optical coherence tomography – a review [invited]. Biomed. Opt. Express 8, 1838 (2017).

    Article 

    Google Scholar
     

  • Wang, N. C. & Yao, J. J. Sound out the deep clarity: super-resolution photoacoustic imaging at depths. IEEE Trans. Ultrason., Ferroelectr., Frequency Control 71, 1801–1813 (2024).

    Article 
    ADS 

    Google Scholar
     

  • Li, M. C. et al. Sound out the deep colors: photoacoustic molecular imaging at new depths. Mol. Imaging 19, 1536012120981518 (2020).

    Article 

    Google Scholar
     



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